oct-7-ynoic acid

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 1-(Hept-6-ynyl)-4-n-propyl-2,6,7-trioxabicyclo[2.2.2]octane was prepared from oct-7-ynoic acid and 3-hydroxymethyl-3-n-propyloxetane using methodology described in Example I.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 4-t-Butyl-1-(hept-6-ynyl)-2,6,7-trioxabicyclo[2.2.2]octane was prepared from oct-7-ynoic acid and 3-t-butyl-3-hydroxymethyloxetane using methodology described in Example I.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 2-(hex-5-ynyl)malonic acid (2.2 g) and cuprous oxide (60mg) in dry acetonitrile (40 ml) was stirred and refluxed, under nitrogen, for 6 hours. The solvent was removed in vacuo. 5% Aqueous hydrochloric acid was added and the aqueous mixture was extracted with diethyl ether. The ethereal extracts were dried over anhydrous magnesium sulphate and the solvent was removed in vacuo. Oct-7-ynoic acid was obtained as an oil (1.5 g) and was used without further purification. refluxed, under nitrogen, for 6 hours The solvent was removed in vacuo 5% Aqueous hydrochloric acid was added the aqueous mixture was extracted with diethyl ether The ethereal extracts were dried over anhydrous magnesium sulphate the solvent was removed in vacuo

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 1-(Hept-6-ynyl)-4-n-propyl-2,6,7-trioxabicyclo[2.2.2]octane was prepared from oct-7-ynoic acid and 3-hydroxymethyl-3-n-propyloxetane using methodology described in Example I.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 4-t-Butyl-1-(hept-6-ynyl)-2,6,7-trioxabicyclo[2.2.2]octane was prepared from oct-7-ynoic acid and 3-t-butyl-3-hydroxymethyloxetane using methodology described in Example I.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 2-(hex-5-ynyl)malonic acid (2.2 g) and cuprous oxide (60mg) in dry acetonitrile (40 ml) was stirred and refluxed, under nitrogen, for 6 hours. The solvent was removed in vacuo. 5% Aqueous hydrochloric acid was added and the aqueous mixture was extracted with diethyl ether. The ethereal extracts were dried over anhydrous magnesium sulphate and the solvent was removed in vacuo. Oct-7-ynoic acid was obtained as an oil (1.5 g) and was used without further purification. refluxed, under nitrogen, for 6 hours The solvent was removed in vacuo 5% Aqueous hydrochloric acid was added the aqueous mixture was extracted with diethyl ether The ethereal extracts were dried over anhydrous magnesium sulphate the solvent was removed in vacuo

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 1-(Hept-6-ynyl)-4-n-propyl-2,6,7-trioxabicyclo[2.2.2]octane was prepared from oct-7-ynoic acid and 3-hydroxymethyl-3-n-propyloxetane using methodology described in Example I.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 4-t-Butyl-1-(hept-6-ynyl)-2,6,7-trioxabicyclo[2.2.2]octane was prepared from oct-7-ynoic acid and 3-t-butyl-3-hydroxymethyloxetane using methodology described in Example I.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 2-(hex-5-ynyl)malonic acid (2.2 g) and cuprous oxide (60 mg) in dry acetonitrile (40 ml) was stirred and refluxed, under nitrogen, for 6 hours. The solvent was removed in vacuo. 5% Aqueous hydrochloric acid was added and the aqueous mixture was extracted with diethyl ether. The ethereal extracts were dried over anhydrous magnesium sulphate and the solvent was removed in vacuo. Oct-7-ynoic acid was obtained as an oil (1.5 g) and was used without further purification. refluxed, under nitrogen, for 6 hours The solvent was removed in vacuo 5% Aqueous hydrochloric acid was added the aqueous mixture was extracted with diethyl ether The ethereal extracts were dried over anhydrous magnesium sulphate the solvent was removed in vacuo

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 1-(Hept-6-ynyl)-4-n-propyl-2,6,7-trioxabicyclo[2.2.2]octane was prepared from oct-7-ynoic acid and 3-hydroxymethyl-3-n-propyloxetane using methodology described in Example I.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 4-t-Butyl-1-(hept-6-ynyl)-2,6,7-trioxabicyclo[2.2.2]octane was prepared from oct-7-ynoic acid and 3-t-butyl-3-hydroxymethyloxetane using methodology described in Example I.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 2-(hex-5-ynyl)malonic acid (2.2 g) and cuprous oxide (60mg) in dry acetonitrile (40 ml) was stirred and refluxed, under nitrogen, for 6 hours. The solvent was removed in vacuo. 5% Aqueous hydrochloric acid was added and the aqueous mixture was extracted with diethyl ether. The ethereal extracts were dried over anhydrous magnesium sulphate and the solvent was removed in vacuo. Oct-7-ynoic acid was obtained as an oil (1.5 g) and was used without further purification. refluxed, under nitrogen, for 6 hours The solvent was removed in vacuo 5% Aqueous hydrochloric acid was added the aqueous mixture was extracted with diethyl ether The ethereal extracts were dried over anhydrous magnesium sulphate the solvent was removed in vacuo