No renderable structure data available
C1=CC=C(C(=C1)S(=O)(=O)N)S(=O)(=O)ClChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2-sulfamoylbenzenesulfonyl chloride |
|---|---|
| IUPAC Name | — |
| CAS Number | 100704-37-8 |
| Database ID | 13849569 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2-sulfamoylbenzenesulfonyl chloride (CAS 100704-37-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 13849569
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
9 reactions · 9 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-5235e564a1d849579e9489db4acbcc07Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 1.28 g of 2-(aminosulfonyl)benzenesulfonyl chloride in 12 ml of dry THF was cooled to -65° C. and a solution of 0.80 ml of cyclopropylamine in 12 ml of dry THF added dropwise. The resulting mixture was allowed to warm to room temperature, filtered, and the filtrate concentrated in vacuo. The solid residue was partitioned between water and ethyl acetate, the organic phase was separated, washed with water, dried (MgSO4), concentrated in vacuo, and the residue triturated with 1-chlorobutane to provide 1.15 g of N-cyclopropyl-1,2-benzenedisulfonamide as a white solid, m.p. 202°-203° C. filtered the filtrate concentrated in vacuo The solid residue was partitioned between water and ethyl acetate the organic phase was separated washed with water dried (MgSO4) concentrated in vacuo the residue triturated with 1-chlorobutane
Source ID: ord-0dddfdaf8078416a8cafa0037f99869fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 1.28 g of 2-(aminosulfonyl)benzenesulfonyl chloride in 12 ml of dry THF was cooled to -65° C. and a solution of 0.80 ml of cyclopropylamine in 12 ml of dry THF added dropwise. The resulting mixture was allowed to warm to room temperature, filtered, and the filtrate concentrated in vacuo. The solid residue was partitioned between water and ethyl acetate, the organic phase was separated, washed with water, dried (MgSO4), concentrated in vacuo, and the residue triturated with 1-chlorobutane to provide 1.15 g of N-cyclopropyl-1,2-benzenedisulfonamide as a white solid, m.p. 202°-203° C. filtered the filtrate concentrated in vacuo The solid residue was partitioned between water and ethyl acetate the organic phase was separated washed with water dried (MgSO4) concentrated in vacuo the residue triturated with 1-chlorobutane
Source ID: ord-0dddfdaf8078416a8cafa0037f99869fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 1.28 g of 2-(aminosulfonyl)benzenesulfonyl chloride in 12 mL of dry tetrahydrofuran (THF) was cooled to -65° C. and a solution of 0.88 mL of 1,1-dimethylhydrazine in 12 mL of dry THF added dropwise. The resulting mixture was allowed to warm to room temperature, filtered, and the filtrate concentrated in vacuo. The solid residue was partitioned between water and ethyl acetate, the organic phase was separated, washed with water, washed with brine, dried (MgSO4), concentrated in vacuo, and the residue triturated with 1-chlorobutane to provide 1.07 g of the subject compound, m.p. 122°-124° C. (dec). filtered the filtrate concentrated in vacuo The solid residue was partitioned between water and ethyl acetate the organic phase was separated washed with water washed with brine dried (MgSO4) concentrated in vacuo the residue triturated with 1-chlorobutane
Source ID: ord-665a3df2f91046edbb1acf755ebc62bdConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-5235e564a1d849579e9489db4acbcc07Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 1.28 g of 2-(aminosulfonyl)benzenesulfonyl chloride in 12 mL of dry tetrahydrofuran (THF) was cooled to -65° C. and a solution of 0.88 mL of 1,1-dimethylhydrazine in 12 mL of dry THF added dropwise. The resulting mixture was allowed to warm to room temperature, filtered, and the filtrate concentrated in vacuo. The solid residue was partitioned between water and ethyl acetate, the organic phase was separated, washed with water, washed with brine, dried (MgSO4), concentrated in vacuo, and the residue triturated with 1-chlorobutane to provide 1.07 g of the subject compound, m.p. 122°-124° C. (dec). filtered the filtrate concentrated in vacuo The solid residue was partitioned between water and ethyl acetate the organic phase was separated washed with water washed with brine dried (MgSO4) concentrated in vacuo the residue triturated with 1-chlorobutane
Source ID: ord-b051e3627c944d079077d038f15ce969Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 1.28 g of 2-(aminosulfonyl)benzenesulfonyl chloride in 12 ml of dry THF was cooled to -65° C. and a solution of 0.80 ml of cyclopropylamine in 12 ml of dry THF added dropwise. The resulting mixture was allowed to warm to room temperature, filtered, and the filtrate concentrated in vacuo. The solid residue was partitioned between water and ethyl acetate, the organic phase was separated, washed with water, dried (MgSO4), concentrated in vacuo, and the residue triturated with 1-chlorobutane to provide 1.15 g of N-cyclopropyl-1,2-benzenedisulfonamide as a white solid, m.p. 202°-203° C. filtered the filtrate concentrated in vacuo The solid residue was partitioned between water and ethyl acetate the organic phase was separated washed with water dried (MgSO4) concentrated in vacuo the residue triturated with 1-chlorobutane
Source ID: ord-e02ba1deb1574177bc3e0704383b48a8Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 1.28 g of 2-(aminosulfonyl)benzenesulfonyl chloride in 12 ml of dry THF was cooled to -65° C. and a solution of 0.80 ml of cyclopropylamine in 12 ml of dry THF added dropwise. The resulting mixture was allowed to warm to room temperature, filtered, and the filtrate concentrated in vacuo. The solid residue was partitioned between water and ethyl acetate, the organic phase was separated, washed with water, dried (MgSO4), concentrated in vacuo, and the residue triturated with 1-chlorobutane to provide 1.15 g of N-cyclopropyl-1,2-benzenedisulfonamide as a white solid, m.p. 202°-203° C. filtered the filtrate concentrated in vacuo The solid residue was partitioned between water and ethyl acetate the organic phase was separated washed with water dried (MgSO4) concentrated in vacuo the residue triturated with 1-chlorobutane
Source ID: ord-0dddfdaf8078416a8cafa0037f99869fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 1.28 g of 2-(aminosulfonyl)benzenesulfonyl chloride in 12 mL of dry tetrahydrofuran (THF) was cooled to -65° C. and a solution of 0.88 mL of 1,1-dimethylhydrazine in 12 mL of dry THF added dropwise. The resulting mixture was allowed to warm to room temperature, filtered, and the filtrate concentrated in vacuo. The solid residue was partitioned between water and ethyl acetate, the organic phase was separated, washed with water, washed with brine, dried (MgSO4), concentrated in vacuo, and the residue triturated with 1-chlorobutane to provide 1.07 g of the subject compound, m.p. 122°-124° C. (dec). filtered the filtrate concentrated in vacuo The solid residue was partitioned between water and ethyl acetate the organic phase was separated washed with water washed with brine dried (MgSO4) concentrated in vacuo the residue triturated with 1-chlorobutane
Source ID: ord-665a3df2f91046edbb1acf755ebc62bdPubChem References
These sources are listed in the compound's public database record.
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